研究業績

ニュース

  • 私たちの研究グループが開発した現場化学センサ群を使って沖縄本島沖合・北東伊是名海域において新規熱水鉱床探査に挑み、新たな海底熱水活動を発見しました。詳しくはこちら

受賞

  • 大学院生の中尾洋祐君が「第21回化学とマイクロ・ナノシステム研究会(21st CHEMINAS)」で発表した『肝細胞培養のための生体内環境を模倣したマイクロ流体デバイス』で、ポスター賞を受賞しました(2010年6月)。
  • 大学院生の青木健吾君(2010年3月修士課程修了)が2009年12月のSI2009で発表した『埋め込み型電気浸透流ポンプを搭載したマイクロ流体デバイスの開発』で、計測自動制御学会の「SI部門賞 若手奨励賞」を受賞しました(2010年12月)。

書籍⋅レビュー論文

  • 木村啓志,山本貴富喜,竹内昌治,酒井康行,藤井輝夫: "マイクロ流体デバイスの細胞培養への応用", バイオチップ実用化ハンドブック,NTS (2010) pp.557-563.
  • Kaneda, S. and Fujii, T.: "Integrated microfluidic systems", Part IV Processing Technology, Nano/Micro Biotechnology (Advances in Biochemical Engineering/Biotechnology, Vol.119), Springer-Verlag (2010), pp.179-194.
  • 藤井輝夫: "特集にあたって",月刊バイオインダストリー,Vol.27,No.3 (2010) pp.5-6.
  • 木村啓志,竹内昌治,酒井康行,藤井輝夫: "マイクロ流体技術を応用した受精卵培養システム", 月刊バイオインダストリー,Vol.27,No.3 (2010) pp.43-49.
  • 藤井輝夫: "マイクロ流体デバイスを用いた細胞・組織Showcase構築の試み", 細胞工学,Vol.29,No.4 (2010) pp.360-364.
  • 酒井康行,藤井輝夫,新野俊樹: "再生医療への化学工学の寄与可能性−組織設計・構築と育成−", 再生医療,Vol.9,No.3 (2010) pp.65-70.

原著論文

  • Kaneda, S., Ono, K., Fukuba, T., Nojima, T., Yamamoto, T., and Fujii, T.: "Pneumatic handling of droplets on-demand on a microfluidic device for seamless processing of reaction and electrophoretic separation", Electrophoresis, Vol.31, Issue 22 (2010), pp.3719-3726.
  • Ono, K., Kaneda, S., Shiraishi, T., and Fujii, T.: "Optofluidic tweezer on a chip", Biomicrofluidics, Vol.4, Issue 4 (2010), 043012.
  • Montagne, K., Plasson, R., Sakai, Y., Fujii, T., Rondelez, Y.: "Programming an in vitro DNA oscillator using a molecular networking strategy", Molecular Systems Biology, Vol.7 (2010) 466
  • Chowdhury, M.M., Katsuda, T., Montagne, K., Kimura, H., Nobuhiko, K., Akutsu, H., Ochiya, T., Fujii, T., and Sakai, Y.: "Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor", Biomedical Microdevices., Vol.12, No.6 (2010), pp.1097-1105.
  • Kimura, H., Takeyama, H., Komori, K., Yamamoto, T., Sakai, Y., and Fujii, T.: "Microfluidic device with integrated glucose sensor for cell-based assay in toxicology", Journal of Robotics and Mechatronics, Vol.22, No.5 (2010) pp.594-600.
  • 木村啓志, 庄野裕基, Nazare Pereira-Rodrigues, 山本貴富喜, 酒井康行, 藤井輝夫: "オンチップグルコースセンサによる細胞活性オンライン計測の検討", 電気学会論文誌E, Vol.130, No.10 (2010), pp.476-483.
  • Li, F.-C., Kinoshita, H., Li, X.-B., Oishi, M., Fujii, T., Oshima, M.: "Creation of very-low-Reynolds-number chaotic fluid motions in microchannels using viscoelastic surfactant solution", Experimental Thermal and Fluid Science, Vol.34 (2010) pp.20-27.
  • Pereira-Rodrigues, N., Poleni, P.-E., Guimard, D., Arakawa, Y., Sakai, Y., and Fujii, T.: "Modulation of hepatocarcinoma cell morphology and activity by parylene-C coating on PDMS", PLoS ONE, Vol.5, Issue 3 (2010), e9667.
  • Evenou, F., Fujii, T., and Sakai, Y.: "Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane", Tissue Engineering Part C: Methods, Vol.16, No.2 (2010) pp.311-318.
  • Evenou, F., Fujii, T., and Sakai, Y.: "Spontaneous formation of stably-attached and 3D-organized hepatocyte aggregates on oxygen-permeable polydimethyl-siloxane membranes having 3D microstructures", Biomedical Microdevices, Vol.12 (2010) pp.465-475.
  • Mogi, K., and Fujii, T.: "A microfluidic device for stepwise size-based capturing of suspended particles", Journal of Micromechanics and Microengineering, Vol.20 (2010) 055015.
  • Yamamoto, T., and Fujii, T.: "Nanofluidic single-molecule sorting of DNA: A new concept in separation and analysis of biomolecule toward ultimate level performance", Nanotechnology, Vol. 21, No. 39 (2010) 395502.

招待講演

  • Fujii, T.: "Cell and tissue cultures in control - From embryos to stem cells", Lorentz Workshop on Micro- and Nanofluidics for Cell Biology, Leiden, The Netherlands (2010).
  • 藤井輝夫: "マイクロ流体デバイスのマイクロ化!?に向けて", 第21回 化学とマイクロ・ナノシステム研究会(21st CHEMINAS),東京 (2010).
  • Fukuba, T., Provin, C., Kinoshita, H., Kusunoki, T., Kyo, M., Shitashima, K., Okamura, K., and Fujii, T.: "Miniaturization of in situ chemical/biochemical analyzers - Application of microfluidic technology", International Symposium on the Deepest Environment on Earth, Chiba, Japan (2010).

講演論文(査読付)

  • Kawada, J., Kimura, H., Akutsu, H., Sakai, Y., and Fujii, T.: "Microfluidic spatial control of stem cell differentiation", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.7-9.
  • Kinoshita, H., Atsumi, T., Fukuba, T., and Fujii, T.: "Active micro flow-rate regulation technique based on soft membrane deformation using miniaturized electroosmotic pumps", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.390-392.
  • Oishi, M., Kinoshita, H., Fujii, T., and Oshima, M.: "Measurement of three dimensional flow structure of droplet formation mechanism in T-shaped junction using phase-locked confocal micro-PIV", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.569-571.
  • Kaneda, S., Minamisawa, T., Shiba, K., and Fujii, T.: "A peptide aptamer-coated surface for selective adhesion of cancer cells in blood cells suspension", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.935-937.
  • Ginet, P., Montagne, K., Akiyama, S., Sakai, Y., Fujii, T., Fourmy, D., Voltz, S., and Kim, B.J.: "Heat-shocl protein synthesis in animal cells induced by gold microheaters", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.977-979.
  • Kinoshita, H., Aoki, K., Yanagisawa, I., and Fujii, T.: "Miniaturization of integrated microfluidic systems", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.1397-1399.
  • Kimura, H., Nakamura, H., Kurakazu, T., Yamamoto, T., Takeuchi, S., Sakai, Y., and Fujii, T.: "An automated embryo culture system using dynamic microarray", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.1544-1546.
  • Yamamoto, T., and Fujii, T.: "Nanofluidic single-molecule sorter conceptually proven by sorting of DNA", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.1874-1876.
  • Matsui, H., Kimura, H., Osada, T., Sekijima, M., Fujii, T., Takeuchi, S., and Sakai, Y.: "Fine regulation of polarity in a hepatocyte culture utilizing oxygen-permeable membranes and micropatterned collagen gel", Proceedings of MicroTAS 2010 conference, Groningen,The Netherlands (2010), pp.2117-2119.
  • Aoki, K., Kinoshita, H., Yanagisawa, I., and Fujii, T.: "Development of integrated multi-pump array for microfluidic applications" Conference Proceedings of International Symposium on Microchemistry and Microsystems (ISMM 2010), Hong Kong (2010), pp.57-58.
  • Kaneda, S., Minamisawa, T., Shiba, K., and Fujii, T.: "Adhesion of cancer cells to a peptide aptamer-coated microchannel" Conference Proceedings of International Symposium on Microchemistry and Microsystems (ISMM 2010), Hong Kong (2010), pp.98-99.
  • Kimura, H., Takeyama, H., Komori, K., Sakai, Y., and Fujii, T.: "Microfluidic device with integrated electrochemical sensor for cell-based assay in toxicology" Conference Proceedings of International Symposium on Microchemistry and Microsystems (ISMM 2010), Hong Kong (2010), pp.110-111.
  • Mogi, K., Paasikallio, T., Pitkanen, J.-P., Penttila, M., and Fujii, T.: "Properties of three thermosetting resins as a microfluidic device" Conference Proceedings of International Symposium on Microchemistry and Microsystems (ISMM 2010), Hong Kong (2010), pp.175-176.
  • Park, K.D., Takama, N., Fujii, T., Fujita, H., and Kim, B.J.: "Entropic trapping migration of DNA molecules in silicon-based nanofluidic channels fabricated by shadow evaporation and wet anisotropic etching in KOH solution", Technical Digest of The 13th International Meeting on Chemical Sensors (IMCS-13), Perth, Australia (2010), p.319.
  • Kusunoki, T., Fukuba, T., Kyo, M., and Fujii, T.: "Development and evaluation of a pH sensor with microfluidic device, Towards reliable pH measurement in deep-sea environment", Techno-Ocean 2010, Kobe, Japan (2010), 27
  • Kim, S. H., Rondelez, Y., Takeuchi, S., Yoshizawa, S., Fourmy, D., and Fujii, T.: "Microchamber array for cell-free protein synthesis from single DNA molecules", The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Hawaii, USA (2010), #545.
  • Kawada, J., Kimura, H., Akutsu, H., Sakai, Y., and Fujii, T.: "Spatially controlled differentiation of pluripotent stem cells in microenvironment", The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Hawaii, USA (2010), #108.
  • Nojima, T., Yamamoto, T., Kimura, H., and Fujii, T.: "PCR-based biomolecular logic gate", The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Hawaii, USA (2010), #872.
  • Kimura, H., Nakamura, H., Akai, T., Yamamoto, T., Hattori, H., Sakai, Y., and Fujii, T.: "Microfluidic device for single embryo coculture with microporous membrane-supported endometrial cells", The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Hawaii, USA (2010), #527.
  • Kaneda, S., Minamisawa, T., Shiba, K., and Fujii, T.: "Selective adhesion of target cancer cells from red blood cell suspension using a peptide aptamer-coated microfluidic device", The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010), Hawaii, USA (2010), #529.

その他の研究発表

  • 福場辰洋,木下晴之,プロヴァン クリストフ,許正憲,藤井輝夫: "マイクロ流体デバイスを応用した海洋環境計測", 第21回 化学とマイクロ・ナノシステム研究会(21st CHEMINAS)講演要旨集, 東京(2010),p.53.
  • Provin, C., Fukuba, T., Okamura, K., and Fujii, T.: "Integrated in situ analyzer for manganese detection (IISA-Mn)", 第21回 化学とマイクロ・ナノシステム研究会(21st CHEMINAS)講演要旨集, 東京(2010),p.65.
  • 楠智行,福場辰洋,許正憲,下島公紀,藤井輝夫: "極限環境における高精度pH計測のための現場校正ISFETの開発", 第21回 化学とマイクロ・ナノシステム研究会(21st CHEMINAS)講演要旨集, 東京(2010),p.84.
  • 中尾洋祐,川田治良,木村啓志,酒井康行,藤井輝夫: "肝細胞培養のための生体内環境を模倣したマイクロ流体デバイス", 第21回 化学とマイクロ・ナノシステム研究会(21st CHEMINAS)講演要旨集, 東京(2010),p.77.
  • 木村啓志,中村寛子,倉員智瑛,竹内昌治,酒井康行,藤井輝夫: "マイクロ流体デバイスを応用した胚培養自動化システム", 第22回 化学とマイクロ・ナノシステム研究会(22nd CHEMINAS)講演要旨集, 名古屋(2010),p.71.
  • 中尾洋佑,川田治良,木村啓志,酒井康行,藤井輝夫: "肝細胞索構造を模倣したマイクロ流体デバイス", 第11回(社)計測自動制御学会システムインテグレーション部門講演会(SI2010)概要集, 仙台(2010),p.315.